- Kushandiswa kwezvinhu zvekurapa
- Kushandiswa kwetishu engineering
- Kushandiswa kwekutsva
- Runako application
Collagen imhando yewhite, opaque, branchless fibrous protein, iyo inonyanya kuwanikwa muganda, bone, cartilage, mazino, tendon, ligaments uye tsinga dzeropa dzemhuka.Iyo yakakosha zvakanyanya puroteni yezvimiro zvekubatanidza tishu, uye inoita basa mukutsigira nhengo nekudzivirira muviri.Mumakore achangopfuura, nekuvandudzwa kwe collagen extraction tekinoroji uye nekutsvaga kwakadzama pachimiro chayo uye zvivakwa, biological basa recollagen hydrolysates uye polypeptides zvishoma nezvishoma rave richizivikanwa zvakanyanya.Tsvagiridzo uye kushandiswa kwe collagen kwave hotspot yekutsvagisa mumishonga, chikafu, zvizorwa uye mamwe maindasitiri.
Collagen ipuroteni yepanyama yemuviri.Iyo ine hukama hukuru hweprotein mamorekuru paganda repamusoro, isina simba antigenicity, yakanaka biocompatibility uye biodegradation kuchengetedzwa.Inogona kuderedzwa uye kunyudzwa, uye ine yakanaka kunamatira.Iyo yekuvhiya suture yakagadzirwa ne collagen haina kungova neiyo yakakwira simba seyakasikwa sirika, asi inewo inopinza.Kana yashandiswa, ine yakanakisa platelet aggregation performance, yakanaka hemostatic effect, yakanaka kutsvedzerera uye elasticity.Iyo suture junction haina kusununguka, mutumbi wemuviri hauna kukuvara panguva yekushanda, uye une kunamatira kwakanaka kune vanga.Mumamiriro ezvinhu akajairwa, nguva pfupi chete yekumanikidza inogona kuwana inogutsa hemostatic athari.Saka collagen inogona kugadzirwa kuita hupfu, flat uye spongy hemostatic.Panguva imwecheteyo, kushandiswa kwezvinhu zvekugadzira kana collagen mune zvinotsiva plasma, ganda rekugadzira, tsinga dzeropa rekugadzira, kugadzirisa kwemapfupa uye bhonzo rekugadzira uye immobilized enzyme vatakuri ndeyekutsvagisa kwakanyanya uye kushandiswa.
Collagen ine mapoka akasiyana-siyana anoshanda pane ayo molecular peptide chain, senge hydroxyl, carboxyl uye amino mapoka, ayo ari nyore kutora uye kusunga akasiyana ma enzymes uye masero kuti awane immobilization.Iyo ine hunhu hwehukama hwakanaka nema enzymes uye masero uye kuchinjika kwakasimba.Pamusoro pezvo, collagen iri nyore kugadzira uye kuumba, saka collagen yakacheneswa inogona kugadzirwa kuita akawanda akasiyana mafomu emidziyo, senge membrane, tepi, shiti, chipanje, bhiza, nezvimwewo, asi mashandisirwo emu membrane anonyanya kutaurwa.Kuwedzera kune biodegradability, tishu absorbability, biocompatibility uye isina simba antigenicity, collagen membrane inonyanya kushandiswa mubiomedicine.Iyo ine zvakare anotevera maitiro: yakasimba hydrophilicity, yakakwira tensile simba, derma-senge morphology uye chimiro, uye yakanaka permeability kumvura nemhepo.Bioplasticity inotemerwa neakakwira tensile simba uye yakaderera ductility;Nemapoka akawanda anoshanda, inogona kuchinjika zvakafanira kudzora chiyero chayo che biodegradation.Adjustable solubility (kuzvimba);Iyo ine synergistic mhedzisiro kana ichishandiswa nezvimwe bioactive zvikamu.Inogona kusangana nemishonga;Muchinjikwa-yakabatana kana enzymatic kurapwa kwekutarisa peptides inogona kuderedza antigenicity, inogona kutsaura tupukanana, kuita zviitiko zvemuviri, senge ropa coagulation uye zvimwe zvakanakira.
Mafomu ekushandisa ekiriniki ndeye aqueous solution, gel, granule, sponge uye firimu.Saizvozvo, maumbirwo aya anogona kushandiswa kunonoka kuburitswa kwezvinodhaka.Iko kunonoka kuburitswa kwekushandisa kwe collagen mishonga yakatenderwa kumusika uye iri pasi pekuvandudzwa inonyanya kutarisana neanti-infection uye glaucoma kurapwa muophthalmology, kurapwa kwenzvimbo mukushungurudzika uye kutonga kwehutachiona mukugadzirisa maronda, cervical dysplasia mugynecology uye anesthesia yemuno mukuvhiya. , nezvimwewo.
Yakaparadzirwa zvakanyanya mumatishu ese emuviri wemunhu, collagen chinhu chakakosha mumatishu ese uye inoumba iyo extracellular matrix (ECM), inova yakasikwa tishu scaffold zvinhu.Kubva pamaonero ekushandiswa kwekiriniki, collagen yakashandiswa kugadzira akasiyana etishu engineering scaffolds, senge ganda, pfupa tishu, trachea uye tsinga yeropa scaffolds.Nekudaro, collagen pachayo inogona kukamurwa kuita zvikamu zviviri, zvinoti scaffolds yakagadzirwa yakachena collagen uye composite scaffolds yakagadzirwa nezvimwe zvikamu.Pure collagen tissue engineering scaffolds ine zvakanakira biocompatibility, nyore kugadzirisa, plasticity, uye inogona kusimudzira sero adhesion uye kuwanda, asi kune zvakare kushomeka kwakadai sehurombo hwemagetsi e collagen, inonetsa kuumba mumvura, uye kusakwanisa kutsigira kuvakwa kwetishu. .Kechipiri, matishu matsva panzvimbo yekugadzirisa anoburitsa akasiyana enzymes, ayo anozoita hydrolyze collagen uye achitungamira mukuparara kwe scaffolds, iyo inogona kuvandudzwa ne-cross-linking kana komputa.Biomaterials yakavakirwa pa collagen yakashandiswa zvinobudirira muzvigadzirwa zveinjiniya seganda rekugadzira, bhonzo rekugadzira, cartilage grafts uye nerve catheters.Cartilage defects yakagadziriswa uchishandisa collagen gels akaiswa muchondrocytes uye kuedza kwakaitwa kubatanidza epithelial, endothelial, uye cornea masero kune collagen sponges kuti ikwane corneal tishu.Mamwe anosanganisa stem maseru kubva ku autogenous mesenchymal masero ane collagen gel kugadzira tendon ye posttendinous kugadzirisa.
Mushonga wakagadzirwa nematishu-engineeral artificial adhesive adhesive inoumbwa nedermis uye epithelium ine collagen sezvo matrix inoshandiswa zvakanyanya muhurongwa hwekuunza zvinodhaka ine collagen sechinhu chikuru, iyo inogona kuumba collagen aqueous mhinduro mumhando dzakasiyana dzekutumira zvinodhaka masisitimu.Mienzaniso inosanganisira collagen vadziviriri ve ophthalmology, collagen sponges yekutsva kana kukuvadzwa, zvimedu zveprotein kuendesa, gel mafomu ecollagen, zvigadziriso zvekushandisa zvinodhaka kuburikidza neganda, uye nanoparticles yekutapurirana majini.Pamusoro pezvo, inogona zvakare kushandiswa se substrate yeinjiniya yetishu inosanganisira cell tsika system, scaffold zvinhu zvemidziyo yeropa yekugadzira uye mavharuvhu, nezvimwe.
Autologous skin grafts yanga iri chiyero chepasi rose chekurapa chechipiri - uye chechitatu-degree kutsva.Zvisinei, kune varwere vane kupisa kwakanyanya, kushayikwa kweganda rakakodzera rakave dambudziko guru.Vamwe vanhu vakashandisa bioengineering matekiniki kukura ganda remwana kubva kumasero eganda remwana.Kupisa kunopora mumadhigirii akasiyana mukati memavhiki matatu kusvika kumwedzi gumi nemisere, uye ganda richangokura rinoratidza kushoma hypertrophy uye kuramba.Vamwe vakashandisa synthetic poly-DL-lactate-glycolic acid (PLGA) uye yepanyama collagen kukura matatu-dimensional yeganda remunhu fibroblasts, zvichiratidza kuti: Masero akakura nekukurumidza pamambure ekugadzira uye akakura anenge panguva imwe chete mukati nekunze, uye masero akawedzera uye akavanzika. extracellular matrix yaive yakawanda yunifomu.Kana mafiber akaiswa kumashure kwegonzo, dermal tissue yakakura mushure memavhiki maviri, uye epithelial tissue yakakura mushure memavhiki mana.
Collagen inobviswa kubva paganda remhuka, ganda mukuwedzera kune collagen rinewo hyaluronic acid, chondroitin sulfate uye mamwe proteoglycan, ane huwandu hwakawanda hwemapoka epolar, chinhu chinonyorovesa, uye chine mhedzisiro yekudzivirira tyrosine muganda kuti ishanduke kuita. melanin, saka collagen ine yakasikwa moisturizing, kuchena, anti-wrinkle, freckle uye mamwe mabasa, inogona kushandiswa zvakanyanya muzvigadzirwa zvekunaka.Collagen's chemical composition and structure inoita kuti ive hwaro hwekunaka.Collagen ine chimiro chakafanana kune ganda remunhu collagen.Iyo isiri-mvura-inonyungudika fibrous protein ine shuga.Mamorekuru ayo akapfuma muhuwandu hukuru hweamino acids uye hydrophilic mapoka, uye ine chimwe chiitiko chepamusoro uye kuenderana kwakanaka.Pa70% hunyoro hunoenderana, inogona kuchengetedza 45% yehuremu hwayo.Miedzo yakaratidza kuti mhinduro yakachena ye0.01% collagen inogona kuumba yakanaka-yekuchengetedza mvura layer, ichipa hunyoro hwese hunodiwa neganda.
Nekuwedzera kwezera, kugona kwekugadzira kwefibroblast kunoderera.Kana ganda risina collagen, iyo collagen fibers ichave yakabatanidzwa, zvichiita kuti kuderedzwa kwe intercellular mucoglycans.Ganda richarasikirwa nekunyorova kwayo, elasticity uye kupenya, zvichikonzera kukwegura.Kana ichishandiswa sechinhu chinoshanda muzvizoro, iyo yekupedzisira inogona kupararira kune yakadzika yeganda.Iyo tyrosine yainayo inokwikwidza ne tyrosine muganda uye inosunga kune inokonzeresa nzvimbo ye tyrosinase, nekudaro ichivharira kugadzirwa kwe melanin, kuwedzera basa re collagen muganda, kuchengetedza hunyoro hwe stratum corneum uye kutendeseka kweiyo fiber chimiro. , uye kukurudzira metabolism yeganda reganda.Iine yakanaka moisturizing uye moisturizing effect paganda.Mukutanga kwema1970, bovine collagen yejekiseni yakatanga kuunzwa muUnited States kubvisa makwapa nemakwinya uye kugadzirisa mavanga.
Nguva yekutumira: Jan-04-2023