High-purity shark chondroitin sulfate chinhu chakakosha chehutano hwehutano
Chondroitin sulfate (CS) inokosha glycosaminoglycan iyo yakanyatsobatanidzwa kune mapuroteni kuti aumbe proteoglycans.Inoparadzirwa zvakanyanya mu extracellular matrix uye sero pamusoro pezvinyama zvemhuka, uye chikamu chakakosha chemhuka yekubatanidza tishu, iyo inonyanya kuwanda mu cartilage.Iyo yakakosha chimiro chechondroitin sulfate inoumbwa nekuchinjanisa ligation yeD-glucuronic acid uye N-acetylgalactosamine ne glycosidic bonds, iyo inobatanidzwazve kune yakakosha chikamu cheprotein kuti iite yakaoma proteoglycan chimiro.
Shark-derived chondroitin sulfate imwe yacho, iyo inonzi acidic mucopolysaccharide inogadzirwa kubva kune shark cartilage tissue.Inoratidzika sehupfu chena kana chena-yakafanana, isina kunhuwa, kuravira kwakashata.Chondroitin shark sulfate chimwe chezvikamu zvikuru zvemammalian connective tissue, uye inowanikwa zvakanyanya mu cartilage, bone, tendon, ligaments, sarcolemma, uye masvingo emidziyo yeropa.
Inoshanda sekuchengetedza uye kutsigirwa mune articular cartilage.Kudya zvine mwero kwechondroitin sulfate kunogona kubatsira kuchengetedza shwashwa, kuderedza kuzvimba uye kurwadziwa, kuvandudza kusashanda kwemajoini, uye kuve nekuchengetedzwa kwakanyanya.Inowanzoshandiswa pamwe chete neglucosamine, musanganiswa uyo kliniki inovandudza zvakanyanya pakati nepakati kusvika kumarwadzo akaoma muosteoarthritis uye inokurudzira collagen itsva uye proteoglycans mumachondrocytes.
| Product Name | Shark Chondroitin Sulfate Soidum |
| Origin | Shark Origin |
| Quality Standard | USP40 Standard |
| Chitarisiko | Muchena kusvika kuhupfu chena |
| Nhamba yeCAS | 9082-07-9 |
| Nzira yekugadzira | enzymatic hydrolysis maitiro |
| Protein Content | ≥ 90% neCPC |
| Kurasika paKuomesa | ≤10% |
| Protein Content | ≤6.0% |
| Function | Joint Health Support, Cartilage uye Bone Health |
| Application | Zvokudya zvinowedzera muTablet, Capsules, kana Powder |
| Chitupa cheHalal | Hongu, Halal Yakasimbiswa |
| GMP Status | NSF-GMP |
| Health Certificate | Ehe, Chitupa chehutano chinowanikwa kune tsika yekubvumidza chinangwa |
| Sherufu Hupenyu | Mwedzi 24 kubva pazuva rekugadzira |
| Packing | 25KG/Drum, Inner Packing: Double PE BAGS, Out Packing: Pepa Drum |
| ITEM | KUTAURA | NZIRA YEKUEDZA |
| Chitarisiko | Off-white crystalline powder | Visual |
| Identification | Muenzaniso unosimbisa nereferensi raibhurari | By NIR Spectrometer |
| Iyo infrared absorption spectrum yemuenzaniso inofanira kuratidza maxima chete paawavelengths yakafanana neye chondroitin sulfate sodium WS. | By FTIR Spectrometer | |
| Kuumbwa kwemaDisaccharides: Chiyero chemhinduro yepamusoro kune △DI-4S kune △DI-6S haisi pasi pe1.0 | Enzymatic HPLC | |
| Optical Rotation: Sangana nezvinodiwa zvekutenderera kwemaziso, kutenderera chaiko mune chaiyo bvunzo | USP781S | |
| Assay(Odb) | 90% -105% | HPLC |
| Kurasikirwa Pakuomesa | <12% | USP731 |
| Mapuroteni | <6% | USP |
| Ph (1%H2o Solution) | 4.0-7.0 | USP791 |
| Specific Rotation | -20°~ -30° | USP781S |
| Residue On Ingition (Dry Base) | 20%-30% | USP281 |
| Organic Volatile Residual | NMT0.5% | USP467 |
| Sulfate | ≤0.24% | USP221 |
| Chloride | ≤0.5% | USP221 |
| Kujeka (5%H2o Solution) | <0.35@420nm | USP38 |
| Electrophoretic Purity | NMT2.0% | USP726 |
| Muganho weasina chaiwo disaccharides | ＜10% | Enzymatic HPLC |
| Heavy Metals | ≤10 PPM | ICP-MS |
| Total Plate Count | ≤1000cfu/g | USP2021 |
| Yeast & Mold | ≤100cfu/g | USP2021 |
| Salmonella | Kusavapo | USP2022 |
| E.Coli | Kusavapo | USP2022 |
| Staphylococcus Aureus | Kusavapo | USP2022 |
| Particle Size | Customized zvinoenderana nezvinodiwa zvako | Mumba |
| Bulk Density | >0.55g/ml | Mumba |
Kutanga, chondroitin sulfate inonzi glycosaminoglycan inowanikwa zvakanyanya pane extracellular matrix yematissue.Mupfupa, inonyanya kuwanikwa munharaunda ye chondrocytes uye inokosha chikamu che cartilage extracellular matrix.Mushonga unobatsira shwashwa kuwana mvura uye kudya kunovaka muviri, nokudaro kuita kuti shwashwa rirambe rakanyorova uye rakararuka, uye richibatsira kuchengetedza kushanda zvakanaka kwemajoini.
Chechipiri, iyo physiological effect ye chondroitin sulfate inonyanya kukosha kune articular cartilage.Inogona kusunga mamorekuru emvura, inhale mamorekuru emvura kuita proteoglycan molecules, gobvu the cartilage uye kuwedzera huwandu hwe synovial fluid mugomba rekubatana, kuzora uye kutsigira mubatanidzwa.Nenzira iyi, mubatanidzwa unogona kuderedza kukakavara uye kukanganisa kana uchifamba, kuitira kuti chibatanidza chinogona kufamba zvakasununguka.
Pakupedzisira, chondroitin sulfate inoshandawo mufupa rekugadzira engineering.Vatsvakurudzi vakagadzirira composite hydrogels inobva ku chondroitin sulfate, iyo inosungirira ions inorganic ions uye inokurudzira bone biomineralization, nokudaro inosimudzira kukwanisa kuberekwa patsva kwemapfupa.Izvi zvine maapplication akakosha ekuvhiyiwa kwekiriniki yemapfupa akadai sekugadzirisa chirema chebhonzo uye kubatanidza mapfupa.
1. Kurudzira hutano hwekubatana: Chondroitin sulfate chimwe chezvikamu zvikuru zve articular cartilage, iyo inogona kubatsira articular cartilage kuchengetedza elasticity yayo nemvura, uye nokudaro kuchengetedza basa rinowanzoitwa rekubatana.Nokuwedzera ne chondroitin sulfate, inogona kukurudzira kugadzirisa uye kuvandudzwa kwe articular cartilage, nokudaro kuderedza nzira yekuderera kwekubatana.
2. Deredza marwadzo akabatana: chondroitin sulfate inogona kuderedza kuputika kwechirwere muhutano, kuderedza kukurudzirwa kwekubatana kwe synovium, uye kuderedza marwadzo ekubatana.Izvi zvine mhedzisiro yakakura yekuzorodza marwadzo kune varwere vane majoini zvirwere senge arthritis.
3. Kuvandudza majoini ekufamba: Chondroitin sulfate inovandudza kufamba uye kushanduka kwekubatana nekuwedzera mafuta ekubatanidza uye kuderedza kupesana kwekubatana.Izvi zvinoita kuti mubatanidzwa uwedzere kutsetseka panguva yekufamba, kuderedza kusagadzikana kunokonzerwa nekuoma kwemajoini kana kufamba zvishoma.
4. Chengetedza articular cartilage: Chondroitin sulfate inogona kudzivisa kuora kwe articular cartilage, uye kukurudzira kuumbwa uye kuvharwa kwechondrocytes, kuitira kuti iite basa rekudzivirira articular cartilage.Izvi zvinobatsira kunonoka nzira yekuchembera kwemajoini uye kupera simba.
1. Kupora maronda uye kugadzirisa ganda: Chondroitin sulfate inoita basa rinokosha mukugadzirisa maronda.Inogona kusimudzira kudzoreredzwa uye kugadziriswa kwevanga matishu, kuvandudza elasticity uye kusimba kweganda, uye kubatsira kuderedza kuumbwa kwevanga.Nokudaro, chondroitin sulfate ine zvingangoshandiswa mukuvhiya, kupisa kurapwa uye kugadzirisa ganda.
2. Indasitiri yezvizoro: Pamusana pehutano hwakanaka hwekunyorovesa uye anti-aging effect, chondroitin sulfate inoshandiswawo zvakanyanya mumhizha yezvizoro.Inogona kuwedzerwa kune zvigadzirwa zvekuchengetedza ganda sechinhu chinonyorovesa, zvichibatsira kuchengetedza unyoro hweganda uye kuvandudza kusimba kweganda uye kupenya.Mukuwedzera, chondroitin sulfate inogonawo kudzivisa kugadzirwa kwemahara radicals, kunonoka kukwegura kweganda, uye kuita kuti ganda rive duku uye riine utano.
3. Tissue engineering uye regenerative medicine: Mumunda wekugadzirwa kwetishu uye regenerative mushonga, chondroitin sulfate inoshandiswa sechikamu chekuvakwa kwezvinhu zvebiomimetic stent.Inogona kusanganiswa nemamwe ma biomaterials kugadzira scaffolds ane chaiwo zvimiro uye mabasa ekugadzirisa kana kutsiva akakuvadzwa tishu uye nhengo.Iyo biocompatibility uye bioactivity ye chondroitin sulfate inoita kuti ive yakakosha mumiriri mumunda wetishu engineering.
4. Antitumor effect: Mumakore achangopfuura, zvidzidzo zvakawana kuti chondroitin sulfate inewo antitumor inogona.Inogona kuvharidzira kutanga kwebundu uye kufambira mberi nekugadzirisa kukura, kusiyanisa uye apoptotic maitiro e tumor cell.Kunyange zvazvo tsvakurudzo yakakodzera ichiri muchikamu chekutanga, tarisiro yekushandisa ye chondroitin sulfate mumunda we anti-tumor inotarisirwa.
Chondroitin sulfate uye glucosamine sulfate haisi yemhando imwe chete.Pane mimwe misiyano mukuumbwa kwavo, kushandiswa uye nzira yekuita.
Chondroitin sulfate inonzi glycosaminoglycan ine zvinhu zvakasiyana-siyana zvehupenyu, kusanganisira lipid-regulating uye anti-inflammatory effects.Inoshandiswa zvakanyanya mukurapa osteoarthritis uye inokwanisa kuderedza hutachiona hwehutachiona uye apoptotic maitiro, panguva imwe chete ichideredza kugadzirwa kwe cytokines inoputika, iNOS uye MMPs.Uyezve, chondroitin sulfate inoitawo basa rakakosha mukudzivirira uye kugadziriswa kwearticular cartilage, kubatsira iyo cartilage kurwisa kusagadzikana kwekushushikana pasi pemamiriro akasiyana ekurodha nekuita kuti matishu arambe uye elastic.
Uye glucosamine sulfate ndechimwe chikamu chakakosha, chinonyanya kushandiswa mukudzivirira uye kurapwa kwemhando dzakasiyana-siyana dze osteoarthritis, dzakadai semabvi akabatanidzwa uye hip joint.Inoshanda pane articular cartilage, nekukurudzira chondrocytes kuti ibudise proteoglycans neyakajairwa polysome chimiro, inovandudza kugadzirisa kwechondrocytes, inhibit kukuvadza cartilage enzymes senge collagenase uye phospholipase A2, uye inogona kudzivirira kugadzirwa kwe superoxidized free radicals mumasero akakuvadzwa, nokudaro kunonoka. the pathological process of osteoarthritis uye kufambira mberi kwechirwere, kuvandudza basa rekubatana, kubvisa marwadzo.
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